The OECD-CRP Symposium on AMR in Livestock Production in a One Health Context was held in Edinburgh on 22-24 May 2023. The magnitude and gravity of the antimicrobial resistance (AMR) health crisis has been stressed by national and international commentators and it is clear that there is an imbalance between the attention given to management of antimicrobial use (AMU) and AMR in clinical settings compared to that in livestock production. Since the latter could amount to more than half the global use of antimicrobials, it is important to understand the drivers of their use and the likely health consequences, both direct and indirect. This symposium, sponsored by the OECD's Co-operative Research Programme, focused on specific gaps in our understanding of AMU in livestock systems and the consequences for AMR, approaching the problem from a One Health perspective. Objectivesto review what we do/do not know about AMU across terrestrial livestock and aquaculture, as well as the effects on AMR;to identify the key barriers (technical, economic, behavioural, political) to interventions to modify AMU;to review the modelling methods that allow the approximation of AMU and AMR and impacts of different interventions;to set this knowledge in the broader One Health agenda of science policy communication and curriculum development;to consider priority policy interventions and strategies.Successful models of One Health workingThe event was organised by Prof Dominic Moran and Carys Redman-White in the Global Academy of Agriculture and Food Systems at the University of Edinburgh. It was structured as a 3-day meeting combining formal presentations (keynotes and focused sessions) covering the topics above and exploring successful models of One Health working for policy. This element involved input of experience from University of Edinburgh projects including the Edinburgh AMR Forum, EPIC, and SEBI-L. The ultimate aim is to develop a network for ongoing collaborative projects and expertise to deliver impact in terms of advice to relevant international bodies (WOAH, FAO and WHO) and national governments seeking guidance for implementation of their AMR action plans (NAPs). Image Attendees at the meeting gathered outside the Edinburgh Climate Change Institute on Tuesday afternoon. ProgrammeNote: Where available, recorded talks can be accessed via the link to speakers name.Slides from the speakers are available at the link below.OECD-CRP AMR in Livestock Production in a One Health Context presentationsMonday 22 May, Roslin InstituteWelcome and introductionGeoff Simm, University of EdinburghLieve Herman, OECD CRP Opening plenaryJulie Fitzpatrick, Chief Scientific Adviser (CSA) for ScotlandKeynoteFrank Møller Aarestrup, Danish Technical University — Novel methods to measure the occurrence and transmission of AMR systemsModeling of AMR SystemsMatt Jones, University of Exeter — Statistical modelling of the AMU-AMR relationship in beef cattleCarys Redman-White, University of Edinburgh—Systems modelling approaches to guide AMR interventions of AMREdinburgh AMR Forum - One Health workingTill Bachmann, University of Edinburgh — Showcase of work from the Edinburgh AMR Forum - including Deborah Hoyle (UoE), Shailesh Shrestha (SRUC), Nuno Silva (Moredun Research Institute)Economics and AMRSara Babo Martins, University of Liverpool—Global Burden of Animal Disease programme: assessing the socio-economic burden of AMR in livestockAlex Morgan, ETH, Zurich —Can taxation of veterinary antibiotics reduce antimicrobial resistance?Tuesday 23 May, Edinburgh Climate Change InstituteKeynoteGwen Knight, LSHTM —Modelling for evidence-based interventions against antibiotic resistanceAMR and One HealthDominic Moran, University of Edinburgh—Transdisciplinary objectives in AMR researchGuillaume Lhermie, University of Calgary—Strategic interactions between stakeholders in OH-AMRMathematical modelling of the AMU-AMR relationshipBram Van Bunnik, University of Edinburgh—Differential equations to model the impact of livestock AMUJoão Gabriel Oliveira Marques, University of Edinburgh— Stochasticity in AMR modellingICARSRodolphe Mader — overview of work in ICARSWednesday 24 May, Edinburgh Climate Change InstituteThe science-policy interfaceFernando Mardones, Pontificia Universidad Católica de Chile — Managing AMU in aquaculture: policy and practiceCristina Lanzas, University of North Carolina — Epidemiological modelling in the livestock sectorAdrian Muwonge, University of Edinburgh — Fleming Fund research on AMR in UgandaEPIC: the Scottish Government’s centre of expertise on animal healthGlobal livestock data and AMR inferenceFeaturing work by SEBI-L Supporting Evidence-Based Interventions for Livestock: a B&M Gates-funded initiative and EDINA, University of EdinburghRelated linksGlobal Academy of Agriculture and Food SystemsRoslin InstituteEdinburgh AMR ForumEdinburgh Climate Change InstituteEPIC – Scotland's Centre of Expertise of Animal Disease OutbreaksSupporting Evidence Based Interventions for Livestock (SEBI-L)EdinaProfessor Dominic Moran Publication date 25 May, 2023
