February 2025: Four researchers from the School of Biological Sciences have received Natural Environment Research Council (NERC) grants to push the frontiers of environmental research. NERC grant receivers from L-R: Professor Sarah Reece, Dr Alex Twyford, Dr Susan Johnston, Dr Sandy Hetherington The four grant recipients have each received up to £950,000 to support pure, applied, technology-led or policy driven research but still address, or provide the means to address, clearly defined scientific questions.In particular, these grants are aimed at supporting researchers and innovators to develop and make use of novel, critical technologies including artificial intelligence, engineering biology, and quantum technologies throughout the UKRI investment portfolio. The new projects range from understanding the drivers of parasite-vector interactions, to horizontal gene transfer, and the impact of the spread of land plants. Research grants Daily rhythms: drivers of parasite-vector interactions and parasite evolution PI: Professor Sarah Reece The Earth’s daily rotation dictates the timing of activities for almost all organisms and is assumed to explain the evolution of circadian clocks and daily rhythms. However, the evolutionary ecology of rhythms is poorly understood, especially for parasites/pathogens, for whom the environments experienced inside hosts and vectors changes dramatically over 24 hours. Yet, rhythms play fundamental roles during infections; for example, the time-of-day an infection is acquired by organisms as diverse as insects and mammals can determine whether they survive or succumb. Horizontal gene transfer in flowering plants PI: Dr Alex Twyford Horizontal gene transfer (HGT)—the acquisition of genetic material from another organism without sexual reproduction—is recognised as being of great importance in prokaryote evolution, where it is responsible for the spread of antibiotic resistance genes among bacterial species. Its importance in eukaryote evolution has long been debated, with early studies erroneously inferring HGT because of contamination in reference genomes. Recent increases in the quality and quantity of reference genomes has led to well-supported examples of HGT of specific genes in particular species. However, the frequency and drivers of HGT, as well as the role that it plays in adaptation, remain unknown. This project addresses the extent and importance of HGT in eukaryotes using large-scale comparative analyses of flowering plants. The causes and consequences of sex differences in meiotic recombination landscapes PI: Dr Susan Johnston Dr Jonhston's NERC project is investigating why the rate and distribution of meiotic crossovers varies between females and males in a long-term study of wild house sparrows, in Helgeland in Norway. The population has been studied in 1993 with information collected on more than 38,000 birds It will incorporate whole genome sequencing and new single-cell technologies to understand the function and evolution of the crossover process. It has implications for evolutionary biology, fertility research, and animal and plant breeding. MapRad: Mapping the radiation of land plants to establish their impact on the Earth System PI: Dr Sandy Hetherington The colonisation of land by plants transformed the Earth; they weathered bedrock, developed the first soils, changed river systems and locked up huge reserves of carbon as biomass. The radiation (spread) of plants is predicted to have caused global cooling, changes in atmospheric CO2 and O2 levels and a mass extinction event. However, linking specific events in plant evolution to these changes, on a causal basis, has proved to be difficult and contentious. This means that our understanding and estimation of the impacts of plant colonisation on the Earth is still unclear. The primary objective of this work is to address this major unresolved question in the natural sciences. Related links Reece LabTwyford LabJohnston LabHetherington LabInstiute of Ecology and EvolutionSchool of Biological SciencesNERC funding call Publication date 10 Feb, 2025